Composite Ion Responsive In Situ Gel Based on Gellan/Carboxymethyl Cellulose Blend for Improved Gelation and Sustained Acyclovir Ocular Release

Quick removal and low therapeutic efficacy are drawbacks of ocular eye drops. In situ gels were developed using gellan gum and/or sodium carboxymethyl cellulose as an ion activated polymer to enhance the residence time drug on surface improve through sustained release acyclovir. The solution containing converted gel cross-linking reaction with Ca++ present in simulated tear fluid. optimized formulation (F1 GC: 0.5 % gum+0.5 cellulose) showed immediate gelation (within 5 s) that remained for more than 6 h may prevent elimination by tears. formulations clear pH range 6.05 7.84. interaction between carboxyl group polymers ions was confirmed Fourier transform infrared spectroscopy. All satisfactory content from 91.13-100.61 %. strength increased concentration increased. prepared exhibited a shear thinning pseudoplastic behaviour help blinking eye. Optimized releases over 8 shows Fickian diffusion mechanism. bioavailability longer contact controlled aunty nude, sex video hindi xxx, mom sex, Indian hidden camera shower, xxx hd full hd, indian couple